Cell penetrating therapeutic agents

M Bally, MP Schultze-Redelmeier… - US Patent App. 10 …, 2005 - Google Patents
This invention is based on the discovery that an internalizing peptide/agent complex Such
as that described above may be conjugated to a lipid-based vehicle without adversely …

Liposomal drug delivery constructs targeted by lipid-conjugated peptide ligands

N Allon, A Saxena, C Chambers… - US Patent App. 12 …, 2009 - Google Patents
(57) ABSTRACT A receptor ligand is conjugated to a lipid-soluble moiety, thereby allowing
effective delivery of the peptide ligand to a target cell in the form of a liposome complex. The …

Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use

WC Shen, H Heiati - US Patent 6,590,071, 2003 - Google Patents
The present invention provides lipidized conjugates com prising an amino group-containing
biologically active Sub stance and a lipophilic group capable of penetrating a biological …

Targeting peptides

A Baker, S Nicklin, S White - US Patent App. 09/990,832, 2003 - Google Patents
Disclosed is an agent which promotes the Selective uptake of material by particular cell
types. In particular, disclosed are targeting peptides which promote uptake of a material by …

Method and carrier complexes for delivering molecules to cells

H Szeto, K Zhao, H Robertson, A Birk - US Patent 8,148,322, 2012 - Google Patents
The invention relates to carrier complexes and methods for delivering molecules to cells.
The carrier complexes com prises a molecule and an aromatic cationic peptide in accor …

Method and carrier complexes for delivering molecules to cells

HH Szeto, K Zhao, HD Robertson, AV Birk - US Patent 7,704,954, 2010 - Google Patents
The invention relates to carrier complexes and methods for delivering molecules to cells.
The carrier complexes com prises a molecule and an aromatic cationic peptide in accor …

Liposomal peptide-lipid conjugates and delivery using same

PR Meers, C Pak, S Ali, A Janoff, JC Franklin… - US Patent …, 2000 - Google Patents
Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the
liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the …

Cell penetrating peptides for intracellular delivery

MDT Chang, SL Fang, WI Chou, SC Lin - US Patent 8,372,951, 2013 - Google Patents
(57) ABSTRACT A cell penetrating peptide which has following sequence: NYBXBXBNQX,
wherein B represents a basic amino acid, X represents an amino acid with an aromatic, a …

Peptide-lipid conjugates, liposomes and lipsomal drug delivery

PR Meers, C Pak, S Ali, A Janoff, JC Franklin… - US Patent …, 2002 - Google Patents
Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the
liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the …

Peptides whose uptake in cells is controllable

R Tsien, T Aguilera, E Olson, T Jiang, Q Nguyen - 2011 - Google Patents
A61K47/50—Medicinal preparations characterised by the non-active ingredients used, eg
carriers or inert additives; Targeting or modifying agents chemically bound to the active …