Traumatic brain injury pathophysiology and treatments: early, intermediate, and late phases post-injury

H Algattas, JH Huang - International journal of molecular sciences, 2013 - mdpi.com
Traumatic Brain Injury (TBI) affects a large proportion and extensive array of individuals in
the population. While precise pathological mechanisms are lacking, the growing base of …

Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …

Pathophysiology of traumatic brain injury

AG Mustafa, OA Alshboul - Neurosciences Journal, 2013 - nsj.org.sa
Traumatic brain injury (TBI) is considered an epidemic that continues to compromise the
welfare of humankind. Despite the extensive efforts invested in countering this clinical health …

A review of the molecular mechanisms of traumatic brain injury

AA Ladak, SA Enam, MT Ibrahim - World neurosurgery, 2019 - Elsevier
Traumatic brain injury (TBI) refers to any insult to the brain resulting in primary (direct) and
secondary (indirect) damage to the brain parenchyma. Secondary damage is often linked to …

Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

TMJC Andriessen, B Jacobs… - Journal of cellular and …, 2010 - Wiley Online Library
Introduction• Classifying TBI‐Clinical injury severity‐Focal injury or diffuse injury• Clinical
characteristics‐Coma, confusion and subacute impairments‐Imaging TBI‐Focal and diffuse …

Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Recent advances in pathophysiology of traumatic brain injury

P Kaur, S Sharma - Current neuropharmacology, 2018 - ingentaconnect.com
Background: Traumatic brain injury (TBI) constitutes the primary reason for mortality and
morbidity in persons worldwide below 45 years of age. 1.7 million Traumatic events occur …

Neuroprotective strategies for traumatic brain injury: improving clinical translation

SV Kabadi, AI Faden - International journal of molecular sciences, 2014 - mdpi.com
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …