The concept that adenosine triphosphate (ATP) can act as an extracellular signaling
molecule via interactions with specific purinergic receptors to mediate a wide variety of …

[Frontiers in Bioscience S3, 1101-1118, June 1, 2011] 1101 P2 receptor expression,
signaling and function in osteoclasts Juan P. Page 1 [Frontiers in Bioscience S3, 1101-1118 …

Abstract ATP (adenosine 5'-triphosphate) is one of the most important extracellular
regulatory molecules in the skeleton. Extracellular ATP and other nucleotides signal through …

Extracellular nucleotides acting through P2 receptors elicit a wide range of responses in
many cell types. There is increasing evidence that adenosine triphosphate (ATP) may …

Nucleotides released from cells in response to mechanical stimulation or injury may serve
as paracrine regulators of bone cell function. Extracellular nucleotides bind to multiple …

Bone development and homeostasis require the interplay between several cell types,
including mesenchymal osteoblasts and osteocytes, as well as hematopoietic osteoclasts …

Extracellular nucleotides, signalling through P2 receptors, regulate the function of both
osteoblasts and osteoclasts. Osteoblasts are known to express multiple P2 receptor …

Bone is a highly dynamic organ, being constantly modeled and remodeled in order to adapt
to the changing need throughout life. Bone turnover involves the coordinated actions of …

The P2X7 nucleotide receptor is an ATP-gated ion channel expressed widely in cells of
hematopoietic origin. Our purpose was to explore the involvement of the P2X7 receptor in …

Bone turnover occurs at discreet sites in the remodeling skeleton. The focal nature of this
process indicates that local cues may facilitate the activation of bone cells by systemic …