Developmental studies in fragile X syndrome

KA Razak, KC Dominick, CA Erickson - Journal of neurodevelopmental …, 2020 - Springer
Fragile X syndrome (FXS) is the most common single gene cause of autism and intellectual
disabilities. Humans with FXS exhibit increased anxiety, sensory hypersensitivity, seizures …

Neuroanatomical, molecular genetic, and behavioral correlates of fragile X syndrome

SD Koukoui, A Chaudhuri - Brain research reviews, 2007 - Elsevier
Fragile X syndrome (FXS) is a leading cause of inherited mental retardation. In the vast
majority of cases, this X-linked disorder is due to a CGG expansion in the 5′ untranslated …

Fragile X syndrome

RJ Hagerman, E Berry-Kravis, HC Hazlett… - Nature reviews Disease …, 2017 - nature.com
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism
spectrum disorder, and patients can present with severe behavioural alterations, including …

Modeling fragile X syndrome in the Fmr1 knockout mouse

TM Kazdoba, PT Leach, JL Silverman… - Intractable & rare …, 2014 - jstage.jst.go.jp
Summary Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …

Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins

CM Spencer, E Serysheva… - Human molecular …, 2006 - academic.oup.com
Individuals affected by Fragile X syndrome (FXS) experience cognitive impairment,
hyperactivity, attention deficits, social anxiety and autistic-like behaviors. FXS results from …

Behavioral abnormalities in the Fmr1‐KO2 mouse model of fragile X syndrome: The relevance of early life phases

J Gaudissard, M Ginger, M Premoli, M Memo… - Autism …, 2017 - Wiley Online Library
Fragile X syndrome (FXS) is a developmental disorder caused by a mutation in the X‐linked
FMR1 gene, coding for the FMRP protein which is largely involved in synaptic function. FXS …

Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us

AR Santos, AK Kanellopoulos, C Bagni - Learning & memory, 2014 - learnmem.cshlp.org
The Fragile X syndrome (FXS) is the most frequent form of inherited mental disability and is
considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet …

Epigenetics of fragile X syndrome and fragile X‐related disorders

CM Kraan, DE Godler, DJ Amor - Developmental Medicine & …, 2019 - Wiley Online Library
The fragile X mental retardation 1 gene (FMR 1)‐related disorder fragile X syndrome (FXS)
is the most common heritable form of cognitive impairment and the second most common …

Fragile X syndrome and targeted treatment trials

R Hagerman, J Lauterborn, J Au… - Modeling fragile X …, 2012 - Springer
Work in recent years has revealed an abundance of possible new treatment targets for
fragile X syndrome (FXS). The use of animal models, including the fragile X knockout mouse …

Fragile X syndrome: assessment and treatment implications

AL Reiss, SS Hall - Child and adolescent psychiatric clinics of North …, 2007 - Elsevier
Fragile X syndrome (FraX) is the most common known cause of inherited mental impairment.
FMR1 gene mutations, the cause of FraX, lead to reduced expression of FMR1 protein and …