Introduction To enhance the probability of pharmacodynamic target attainment, piperacillin–
tazobactam can be administered as either a continuous or extended-infusion dosage …

Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …

Administration of β-lactam antibiotics by extended infusion optimizes the pharmacodynamic
properties and bactericidal activity of these agents resulting in a potential improvement in …

Purpose The pharmacodynamics and therapeutic effects of extended-infusion (EI)
piperacillin–tazobactam therapy are reviewed, with an emphasis on growing evidence of its …

Studies evaluating the outcomes of an extended-infusion (EI) piperacillin-tazobactam dosing
strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre …

Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

Background: Current medical center practice allows for the automatic conversion of all
piperacillin/tazobactam orders from intermittent to extended infusion (EI). Objective: To …

Outcomes of extended infusion piperacillin/tazobactam for documented Gram-negative infections -
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Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …