High‐density lipoproteins in the prevention of cardiovascular disease: changing the paradigm

S Tuteja, DJ Rader - Clinical Pharmacology & Therapeutics, 2014 - Wiley Online Library
High‐density‐lipoprotein cholesterol (HDL‐C) has been identified in population studies as
an independent inverse predictor of cardiovascular events. Although the causal nature of …

High density lipoprotein-should we raise it?

U Landmesser - Current vascular pharmacology, 2012 - ingentaconnect.com
Low high-density lipoprotein (HDL) cholesterol levels are associated with an increased risk
of coronary artery disease and myocardial infarction. Experimental studies have identified …

HDL, atherosclerosis, and emerging therapies

A Hafiane, J Genest - Cholesterol, 2013 - Wiley Online Library
This review aims to provide an overview on the properties of high‐density lipoproteins
(HDLs) and their cardioprotective effects. Emergent HDL therapies will be presented in the …

Focus on high-density lipoproteins in reducing cardiovascular risk

HB Brewer Jr - American heart journal, 2004 - Elsevier
Low high-density lipoprotein (HDL) cholesterol is associated with increased risk of coronary
heart disease (CHD). Ongoing investigation into the mechanisms whereby HDL cholesterol …

HDL therapy for the treatment of cardiovascular diseases

C Parolini, M Marchesi, G Chiesa - Current vascular …, 2009 - ingentaconnect.com
High-density lipoprotein (HDL) therapy is an emerging area of therapeutic development in
the cardiovascular field, aimed at supplementing and improving the vascular benefit exerted …

High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions

P Barter, J Kastelein, A Nunn, R Hobbs, FFE Board - Atherosclerosis, 2003 - Elsevier
The concentration of high density lipoprotein-cholesterol (HDL-C) has been found
consistently to be a powerful negative predictor of premature coronary heart disease (CHD) …

HDL-cholesterol and cardiovascular disease: rethinking our approach

HK Siddiqi, D Kiss, D Rader - Current opinion in cardiology, 2015 - journals.lww.com
HDL-cholesterol and cardiovascular disease: rethinking our a... : Current Opinion in
Cardiology HDL-cholesterol and cardiovascular disease: rethinking our approach : Current …

Why targeting HDL should work as a therapeutic tool, but has not

MG Sorci-Thomas, MJ Thomas - Journal of cardiovascular …, 2013 - journals.lww.com
Atherosclerosis is one of the most common causes of death and disability in the United
States today despite the availability of statins, which reduce hyperlipidemia, a risk factor that …

High-density lipoproteins and cardiovascular disease: 2010 update

K Alwaili, Z Awan, A Alshahrani… - Expert review of …, 2010 - Taylor & Francis
High-density lipoprotein-cholesterol (HDL-C) is a continuous inverse cardiovascular risk
factor. The mechanisms by which HDLs protect against atherosclerosis are multiple. The …

[HTML][HTML] The role of lipids and lipoproteins in atherosclerosis

MRF Linton, PG Yancey, SS Davies, WG Jerome… - Endotext …, 2019 - ncbi.nlm.nih.gov
Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …