The formation of carcinogen-DNA adducts within the respiratory epithelium is thought to be a
critical factor in the induction of lung cancer from tobacco smoke. A reliable surrogate …

BACKGROUND: DNA adducts formed as a consequence of exposure to tobacco smoke may
be involved in carcinogenesis, and their presence may indicate a high risk of lung cancer …

The presence of carcinogen‐DNA adducts in human tissues is evidence of exposure to
carcinogens and may be an indicator of cancer risk. DNA was isolated from non‐tumorous …

The 32P-post-labelling assay for DNA adduct quantification gives the opportunity to examine
endogenous exposure to DNA reactive compounds. Most human biomonitoring studies …

Covalent DNA addition products (adducts) formed by the reaction of chemical carcinogens
or their metabolites with DNA are critically involved in the initiation of chemical …

Tobacco smoking causes millions of cancer deaths annually. Tobacco smoke is a complex
mixture of thousands of chemicals including many known animal carcinogens. Because …

The levels of aromatic/hydrophobic DNA adducts were analyzed in normal lung tissue from
63 lung cancer patients and examined in relation to exposure and genetic factors. Adduct …

Polycyclic aromatic hydrocarbon-DNA adducts were measured by ELISA in peripheral
leukocytes from 119 non-small cell lung cancer patients and 98 controls at the Columbia …

In this matched case-control study nested within the prospective Physicians' Health Study,
we evaluated whether DNA damage in blood samples collected at enrollment significantly …

The purpose of this study was to examine the level of smoking‐related aromatic DNA
adducts and oxidative DNA damage in current smokers from a lung cancer case‐control …