Background Limited controlled data exist to guide treatment choices for clinicians caring for
patients with major depressive disorder (MDD). Although many putative predictors of …

Objective: Antidepressants (ADs) are the mainstay of treatment for major depressive
disorder (MDD). Despite their widespread usage, a consensus does not exist as to the …

Introduction Major depressive disorder is a complex and frequent psychiatric condition that
poses significant challenges to both the patients who experience it and the physicians who …

Background It remains unclear regarding the contribution of each individual symptom in
predicting the outcome in major depressive disorder (MDD). The objective of this analysis …

Objective: The Predictors of Remission in Depression to Individual and Combined
Treatments [PReDICT] study aimed to identify clinical and biological factors predictive of …

Although antidepressants are effective, no more than one third of the depressed patients
who begin treatment achieve full remission within 8 weeks of therapy. Remission, defined as …

Objective: Few data exist to help clinicians predict likelihood of treatment response in
individual patients with major depressive disorder (MDD). Our aim was to identify subgroups …

The probability of achieving and sustaining symptomatic remission in major depressive
disorder (MDD) with first-line pharmacotherapy is approximately 30%. Ample documentation …

Depression is the fourth-largest contributor to the global burden of disease, and it causes
profound suffering and extreme costs to health care systems and society. Although there …

For more than a decade, the goal of major depressive disorder treatment has been
achieving and sustaining remission, which involves complete resolution of depressive …