Safety and efficacy of a cytomegalovirus glycoprotein B (gB) vaccine in adolescent girls: A randomized clinical trial

DI Bernstein, FM Munoz, ST Callahan, R Rupp… - Vaccine, 2016 - Elsevier
Background Cytomegalovirus (CMV) is a leading cause of congenital infection and an
important target for vaccine development. Methods CMV seronegative girls between 12 and …

Immunogenicity of a recombinant human cytomegalovirus gB vaccine in seronegative toddlers

DK Mitchell, SJ Holmes, RL Burke… - The Pediatric …, 2002 - journals.lww.com
Background. Immunization of young children against cytomegalovirus (CMV) might
decrease child-to-child and child-to-adult transmission of CMV and thereby reduce maternal …

Development and evidence for efficacy of CMV glycoprotein B vaccine with MF59 adjuvant

RF Pass - Journal of clinical virology, 2009 - Elsevier
A vaccine comprised of recombinant cytomegalovirus (CMV) envelope glycoprotein B (gB)
with MF59 adjuvant developed in the 1990s recently was recently found to have efficacy for …

Effect of previous or simultaneous immunization with canarypox expressing cytomegalovirus (CMV) glycoprotein B (gB) on response to subunit gB vaccine plus MF59 …

DI Bernstein, MR Schleiss, K Berencsi… - The Journal of …, 2002 - academic.oup.com
Abstract Development of a vaccine for prevention of congenital cytomegalovirus (CMV)
disease is a priority. This study evaluated a “prime-boost” strategy by comparing the safety …

Vaccine prevention of maternal cytomegalovirus infection

RF Pass, C Zhang, A Evans, T Simpson… - … England Journal of …, 2009 - Mass Medical Soc
Background Congenital infection with cytomegalovirus (CMV) is an important cause of
hearing, cognitive, and motor impairments in newborns. Methods In this phase 2, placebo …

Update on the current status of cytomegalovirus vaccines

H Sung, MR Schleiss - Expert review of vaccines, 2010 - Taylor & Francis
Human cytomegalovirus (HCMV) is ubiquitous in all populations, and is the most commonly
recognized cause of congenital viral infection in developed countries. On the basis of the …

[HTML][HTML] Cytomegalovirus vaccines under clinical development

MR Schleiss - Journal of virus eradication, 2016 - Elsevier
Congenital cytomegalovirus (CMV) infection is the most common infectious cause of
disability in newborn infants. CMV also causes serious disease in solid organ (SOT) and …

Progress toward development of a vaccine against congenital cytomegalovirus infection

MR Schleiss, SR Permar, SA Plotkin - Clinical and Vaccine …, 2017 - Am Soc Microbiol
ABSTRACT A vaccine against congenital human cytomegalovirus (CMV) infection is a major
public health priority. Congenital CMV causes substantial long-term morbidity, particularly …

[HTML][HTML] Cytomegalovirus vaccines: current status and future prospects

KM Anderholm, CJ Bierle, MR Schleiss - Drugs, 2016 - Springer
Congenital human cytomegalovirus (HCMV) infection can result in severe and permanent
neurological injury in newborns, and vaccine development is accordingly a major public …

Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans

JA Jenks, CS Nelson, HK Roark, ML Goodwin… - Science translational …, 2020 - science.org
Human cytomegalovirus (CMV) is the most common infectious cause of infant brain damage
and posttransplant complications worldwide. Despite the high global burden of disease …