Comparison of sequential cytomegalovirus isolates in a patient with lymphoma and failing antiviral therapy

A Ducancelle, S Belloc, S Alain, C Scieux… - Journal of clinical …, 2004 - Elsevier
Background: Long-term anti-cytomegalovirus (CMV) treatments in immunocompromised
patients are hampered by resistance to antiviral drugs. Longitudinal changes in the …

Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients

A Erice, C Gil-Roda, JL Pérez… - Journal of Infectious …, 1997 - academic.oup.com
Antiviral susceptibilities to ganciclovir, foscarnet, and cidofovir and sequencing of UL97 and
DNA polymerase were done on 23 cytomegalovirus (CMV) isolates from 10 …

Resistance of human cytomegalovirus to antiviral drugs

A Erice - Clinical Microbiology Reviews, 1999 - Am Soc Microbiol
Resistance of cytomegalovirus (CMV) to antiviral agents is a well-recognized phenomenon
that has been observed in the laboratory and in the clinical setting. Infections caused by …

Resistance to antivirals in human cytomegalovirus: mechanisms and clinical significance.

JL Perez - Microbiologia (Madrid, Spain), 1997 - europepmc.org
Long term therapies needed for managing human cytomegalovirus (HCMV) infections in
immunosupressed patients provided the background for the emergence of the resistance to …

A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance

S Chou, RC Miner, WL Drew - The Journal of infectious diseases, 2000 - academic.oup.com
A patient with AIDS and cytomegalovirus (CMV) retinitis received ganciclovir and foscarnet
for 20 and 5 months, respectively, with evidence of periodic disease progression. After this …

Ganciclovir resistance and UL97 gene mutations in cytomegalovirus blood isolates from patients with AIDS treated with ganciclovir

B Abraham, S Lastere, J Reynes… - Journal of clinical …, 1999 - Elsevier
Background: Treatment of cytomegalovirus (CMV) diseases with protracted administration of
ganciclovir can promote the development of resistant CMV that is associated with a poor …

Aciclovir selects for ganciclovir‐cross‐resistance of human cytomegalovirus in vitro that is only in part explained by known mutations in the UL97 protein

D Michel, S Höhn, T Haller, D Jun… - Journal of medical …, 2001 - Wiley Online Library
Phenotypically, ganciclovir‐resistant human cytomegalovirus strains could be selected by
aciclovir as effectively as by ganciclovir in vitro. Three clinical human cytomegalovirus …

Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene

S Chou, LC Van Wechel, HM Lichy… - Antimicrobial agents …, 2005 - Am Soc Microbiol
ABSTRACT A new recombinant phenotyping method was developed for the analysis of drug
resistance mutations in human cytomegalovirus (CMV). CMV strain T2211 was derived from …

Ganciclovir susceptibilities and analysis of UL97 region in cytomegalovirus (CMV) isolates from bone marrow recipients with CMV disease after antiviral prophylaxis

A Erice, N Borrell, W Li, WJ Miller… - Journal of Infectious …, 1998 - academic.oup.com
Ganciclovir susceptibilities and UL97 sequences were analyzed in 20 cytomegalovirus
(CMV) isolates recovered from 15 bone marrow transplant recipients with active CMV …

Emergence and persistence of multiple antiviral-resistant CMV strains in a highly immunocompromised child

JM Iwasenko, GM Scott, JB Ziegler… - Journal of clinical …, 2007 - Elsevier
BACKGROUND: The emergence of human cytomegalovirus (CMV) antiviral resistance plays
a significant role in disease progression in immunocompromised patients who have …