The Arf GAPs are a structurally diverse group of proteins that catalyze the hydrolysis of GTP
bound to Arf1. Here, we directly compare the role of amino acids 2–17 of Arf1, a GTP-and …

We previously characterized a Gα12-specific signaling pathway that stimulates the
transcription of the E3 ligase RFFL via the protein kinase ARAF and ERK. This pathway …

Tamoxifen, a selective estrogen receptor (ER) modulator (SERM), remains a frontline clinical
therapy for patients with ERα-positive breast cancer. However, the relatively rapid …

Background: Metastasis is the primary cause of death in most human cancers, and
understanding the molecular mechanisms underpinning this multistep process is …

Tumor cell invasion through the extracellular matrix is accompanied by the formation of
invadopodia, which are actin-rich protrusions at the adherent surface of cells at sites of …

Arf6 and its effector AMAP1 are overexpressed in malignant breast cancer cells, and are
involved in their invasion and metastasis. We recently revealed that GEP100, a guanine …

The adaptor protein growth factor receptor-bound protein 2 (Grb2) is ubiquitously expressed
in eukaryotic cells and involved in a multitude of intracellular protein interactions. Grb2 plays …

Arf1 is a GTP binding protein that functions at a number of cellular sites to control membrane
traffic and actin remodeling. Arf1 is regulated by site-specific GTPase-activating proteins …

Background: Fibroblast growth factors receptors (FGFRs) are involved in estrogen-
independent breast cancer cell growth. Grb14, a member of the Grb7 family of adapters, is …

TGFBR1* 6A is a common hypomorphic variant of the type 1 transforming growth factor β
receptor (TGFBR1), which has been associated with increased cancer risk in some studies …