Abstract The interleukin (IL)-1 family consists of 11 members, which all play significant roles
in regulating inflammatory responses in the host. IL-1α and IL-1β exert potent pro …

Many aspects of antimicrobial host responses are orchestrated by a complex network of
cytokines and their receptors. This review focuses on recent progress in our understanding …

Aspergillus is a saprophytic fungus, which mainly becomes pathogenic in
immunosuppressed hosts. A failure of host defences results in a diverse set of illnesses …

Aspergillosis is a fungal infection caused by various species of Aspergillus, most notably A.
fumigatus. This fungus causes a spectrum of diseases, including allergic bronchopulmonary …

There is substantial evidence that the production of proinflammatory cytokines is important in
host resistance to invasive aspergillosis. Knowledge of the host response towards other …

The ubiquitous opportunistic fungal pathogen Aspergillus fumigatus rarely causes infections
in immunocompetent individuals. A healthy functional innate immune system plays a crucial …

Invasive aspergillosis (IA) remains a major cause of morbidity in immunocompromised
hosts. This is due to the inability of the host immunity to respond appropriately to Aspergillus …

Highlights•Host-fungal interactions tune the innate inflammatory response to maintain host
resistance against distinct fungal isolates.•Growth, viability, phagosome escape, and cell …

Invasive aspergillosis (IA) is one of the most difficult to treat and, consequently, one of the
most lethal fungal infections known to man. Continued use of immunosuppressive agents …

The outcome of the Th1/Th2 balance is a critical determinant of the outcome in invasive
aspergillosis. The innate immune system encounters the pathogen first. Dendritic cells (DC) …