Microsatellite instability is an important characteristic of many tumor types1–8 especially
those associated with hereditary non–polyposis colorectal carcinoma (HNPCC) syndrome6 …

Microsatellite DNA alterations are an integral part of neoplastic progression and are
valuable as clonal markers for the detection of human cancers1–3. Moreover, recent …

Microsatellite instability has been reported to be an important feature of tumors from
hereditary nonpolyposis colorectal carcinoma (HNPCC) patients. The recent discovery of …

Alterations in microsatellite sequences characterize hereditary nonpolyposis colorectal
cancer. This microsatellite instability is due in some kindreds to a germline mutation of the …

Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed
throughout the genome. Instability of these repeat sequences at multiple genetic loci may …

We have analyzed DNA obtained from 38 lung tumors and normal lung or blood DNA for
microsatellite instability. Instability was examined at 10 different microsatellite loci on …

Microsatellite mutations are useful markers of both tumor clonality and genomic instability
but the origin of the mutator mutations responsible is still not well understood (pages 676 …

The allele sizes of polymorphic microsatellite repeats in DNA from human cancers were
compared to normal DNA from the same patients. In 16 out of 196 paired samples (8%), we …

A major problem in lung cancer is the lack of clinically useful tests for early diagnosis and
screening of an asymptomatic population by noninvasive diagnostic procedures. Recent …

Early diagnosis of lung cancer based on conventional screening procedures has been
unable thus far to decrease lung cancer mortality. We explored the possibility of using …