Novel GLP-1 (glucagon-like peptide-1) analogues and insulin in the treatment for Alzheimer's disease and other neurodegenerative diseases
V Calsolaro, P Edison - CNS drugs, 2015 - Springer
The link between diabetes mellitus and Alzheimer's disease (AD) has been known for the
last few decades. Since insulin and insulin receptors are known to be present in the brain …
last few decades. Since insulin and insulin receptors are known to be present in the brain …
Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection
C Hölscher - CNS drugs, 2012 - Springer
The current understanding of neurodegenerative processes in sporadic diseases such as
Alzheimer's disease (AD), Parkinson's disease (PD) or multiple sclerosis is very limited …
Alzheimer's disease (AD), Parkinson's disease (PD) or multiple sclerosis is very limited …
Potential roles of glucagon-like peptide-1 and its analogues in dementia targeting impaired insulin secretion and neurodegeneration
Dementia is a chronic, irreversible condition marked by memory loss, cognitive decline, and
mental instability. It is clinically related to various progressive neurological diseases …
mental instability. It is clinically related to various progressive neurological diseases …
The role of GLP-1 in neuronal activity and neurodegeneration
C Hölscher - Vitamins & Hormones, 2010 - Elsevier
Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD). The
underlying mechanism behind this unexpected link is most likely linked to the observed …
underlying mechanism behind this unexpected link is most likely linked to the observed …
Targeting amyloid-beta by glucagon-like peptide-1 (GLP-1) in Alzheimer's disease and diabetes
AM Bak, L Egefjord, M Gejl, C Steffensen… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Epidemiological evidence suggests an association between type 2 diabetes
(T2DM) and Alzheimer's disease (AD), in that one disease increases the risk of the other …
(T2DM) and Alzheimer's disease (AD), in that one disease increases the risk of the other …
Neuroprotective actions of glucagon-like peptide-1 (GLP-1) analogues in Alzheimer's and Parkinson's diseases
The current absence of effective treatments for Alzheimer's disease (AD) and Parkinson's
disease (PD) reflects an incomplete knowledge of the underlying disease processes …
disease (PD) reflects an incomplete knowledge of the underlying disease processes …
Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease
PL McClean, VA Gault, P Harriott, C Hölscher - European journal of …, 2010 - Elsevier
Type 2 diabetes has been identified as a risk factor for patients with Alzheimer's disease.
Insulin signalling is often impaired in Alzheimer's disease, contributing to the …
Insulin signalling is often impaired in Alzheimer's disease, contributing to the …
A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model
L Shi, Z Zhang, L Li, C Hölscher - Behavioural brain research, 2017 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, accompanied by
memory loss and cognitive impairments, and there is no effective treatment for it at present …
memory loss and cognitive impairments, and there is no effective treatment for it at present …
Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
C Hölscher - Journal of Endocrinology, 2014 - joe.bioscientifica.com
The incretin hormone glucagon-like peptide 1 (GLP-1) has many effects in the body. It is best
known for the 'incretin effect', facilitating insulin release from the pancreas under …
known for the 'incretin effect', facilitating insulin release from the pancreas under …
Protective properties of GLP‐1 and associated peptide hormones in neurodegenerative disorders
C Hölscher - British journal of pharmacology, 2022 - Wiley Online Library
Type 2 diabetes mellitus and the associated desensitisation of insulin signalling has been
identified as a risk factor for progressive neurodegenerative disorders such as Alzheimer's …
identified as a risk factor for progressive neurodegenerative disorders such as Alzheimer's …
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