The extracellular matrix (ECM) critically affects β cell functions via integrin activation. But
whether these ECM actions drive the spatial organization of β cells, as they do in epithelial …

Understanding the organisation and role of the extracellular matrix (ECM) in islets of
Langerhans is critical for maintaining pancreatic β‐cells, and to recognise and revert the …

Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

The integrin receptors link to extracellular matrix proteins and exert a dynamic role in
development by providing the physical basis for cell adhesion and controlling cell growth. In …

Integrin-extracellular matrix interactions are important determinants of beta cell behaviours.
The β1 integrin is a well-known regulator of beta cell activities; however, little is known of its …

Development of the endocrine compartment of the pancreas, as represented by the islets of
Langerhans, occurs through a series of highly regulated events encompassing branching of …

Pancreatic islet β cells are organized in rosette-like structures around blood vessels and
exhibit an artery-to-vein orientation, but they do not display the typical epithelial polarity. It is …

Beta cell connectivity describes the phenomenon whereby the islet context improves insulin
secretion by providing a three-dimensional platform for intercellular signaling processes …