An open study of 47 patients with cancer pain treated with repeated doses of a controlled-
release oral morphine tablet was conducted to assess the acceptability of this drug and …

Eighteen patients suffering from chronic pain due to cancer completed a balanced, double-
blind, double-dummy, two period cross-over trial comparing the pharmacokinetics (PK) and …

Key Points Initiating pain control therapy with low‐dose morphine provided better and faster
pain relief versus weaker opioids among patients with moderate cancer pain. The frequency …

Purpose The WHO guidelines on cancer pain management recommend a sequential three-
step analgesic ladder. However, conclusive data are lacking as to whether moderate pain …

Background: Pain is one of the most prevalent and distressing symptoms in patients with
cancer. There is evidence from observational studies that many patients do not get adequate …

BACKGROUND Pain control is one of the most important goals of end‐of‐life care, and the
use of opioids for this purpose is extremely common in hospice settings. However, it is …

Methadone has been used as an alternative strong opioid to morphine in the management
of cancer pain. The conversion of morphine to methadone is not straightforward because of …

The clinical importance of routine drug monitoring of serum concentrations of morphine,
morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) during chronic …

Materials and Methods: A sample if 41 patients with cancer-related pain in palliative setting
were included. Patients were starting the third step of the analgesic ladder, and 1 group (n …

This randomized controlled trial compared intravenous route with oral route for initial dose
titration of morphine in 62 patients with end-stage cancer and severe pain. Patients in the …