Pain is one of the most feared symptoms for patients who are facing end-of-life issues.
Management of this pain often requires high doses of morphine. Unfortunately, physicians …

One hundred fifty‐one patients with chronic cancer pain were studied during chronic
treatment with oral morphine. Plasma concentrations of morphine and metabolites (M3G and …

Background: Breakthrough pain is an exacerbation of pain occurring in patients with chronic
pain who receive opioid therapy every day. Breakthrough pain has not been routinely …

The aim of the research was to establish the optimal dosage of oral morphine which would
be adequate for pain control, its negative effects, frequency, intensity and the occurrence of …

Twenty‐three adult patients with chronic pain due to cancer completed a double‐blind,
randomized, two‐phase crossover trial comparing plasma morphine concentrations and …

The efficacy, safety, and pharmacokinetics of a novel once-daily morphine formulation (OAD
morphine) and a 12-hourly formulation (twice-daily CR morphine) were compared in a …

Morphine is the dominant medication to control cancer pain. Morphine consumption has
been increasing each year in many countries including Japan based on the understanding …

Background Pain in people with advanced cancer is prevalent. When a stable dose of
opioids is established, people still experience episodic breakthrough pain for which dosing …

Immediate‐release oral morphine, given every four hours in individually titrated doses, is
effective in the control of severe cancer pain. To evaluate the analgesic efficacy of a …