Safety profile of the direct oral anticoagulants: an analysis of the WHO database of adverse drug reactions

L Monaco, C Biagi, V Conti, M Melis… - British journal of …, 2017 - Wiley Online Library
Aim Direct oral anticoagulants (DOACs) have shown noninferiority to warfarin for stroke
prevention in nonvalvular atrial fibrillation (AF) and a more promising safety profile …

[PDF][PDF] Adverse events associated with the use of direct-acting oral anticoagulants in clinical practice: beyond bleeding complications

E Raschi, M Bianchin, W Ageno, R De Ponti… - Pol Arch Med …, 2016 - researchgate.net
Non-vitamin K oral anticoagulants, also known as direct-acting oral anticoagulants (DOACs),
have entered the market in 2008 with the expected breakthrough potential of circumventing …

Major bleeding risk associated with oral anticoagulant in real clinical practice. A multicentre 3‐year period population‐based prospective cohort study

J Bouget, F Balusson, M Maignan… - British Journal of …, 2020 - Wiley Online Library
Aims The objective was to compare major bleeding risk of direct oral anticoagulants
(DOACs; per type and dose) with vitamin K antagonists (VKAs), irrespective of indication …

[HTML][HTML] Safety of direct oral anticoagulants: insights from postmarketing studies

TC Villines, WF Peacock - The American Journal of Medicine, 2016 - Elsevier
Direct oral anticoagulants (DOACs) have been marketed in the United States since 2010.
While numerous large-scale prospective phase 3 outcomes studies have documented the …

Relevance of physicochemical properties and functional pharmacology data to predict the clinical safety profile of direct oral anticoagulants

CJ Ferro, F Solkhon, Z Jalal… - Pharmacology …, 2020 - Wiley Online Library
Direct oral anticoagulants (DOACs) have rapidly become the drug class of choice for
anticoagulation therapy in secondary care. It is known that gastrointestinal hemorrhage are …

[HTML][HTML] Anticoagulant-associated adverse drug reactions in 2013–15

AK Eek, BO Strøm, G Bakkehøi… - Tidsskrift for Den …, 2018 - tidsskriftet.no
Anticoagulant-associated adverse drug reactions in 2013–15 | Tidsskrift for Den norske
legeforening Skip to main content Toggle navigation Artikler Fagområder Utgaver Podkast …

Safety of direct oral anticoagulants in real–world clinical practice: translating the trials to everyday clinical management

AM Fawzy, WY Yang, GYH Lip - Expert Opinion on Drug Safety, 2019 - Taylor & Francis
ABSTRACT Introduction: Direct oral anticoagulants (DOACs) may be regarded as some of
the most successful innovations in recent times. These drugs which were specifically …

Use of direct oral anticoagulants in patients with atrial fibrillation in Scotland: applying a coherent framework to drug utilisation studies

T Mueller, S Alvarez‐Madrazo… - … and Drug Safety, 2017 - Wiley Online Library
Purpose To report the use of direct oral anticoagulants (DOACs) for stroke prevention in
patients with atrial fibrillation in Scotland and advocate the standardisation of drug utilisation …

[HTML][HTML] Direct oral anticoagulants for the prevention of stroke in patients with nonvalvular atrial fibrillation: understanding differences and similarities

PP Dobesh, J Fanikos - Drugs, 2015 - Springer
The presence of atrial fibrillation (AF), the most common sustained cardiac arrhythmia,
significantly increases the risk for stroke. Current guidelines recommend that the vitamin K …

Comparative safety and effectiveness of direct oral anticoagulants in patients with atrial fibrillation in clinical practice in Scotland

T Mueller, S Alvarez‐Madrazo… - British journal of …, 2019 - Wiley Online Library
Aims The aim of this study was to compare the clinical effectiveness and safety of direct oral
anticoagulants (DOACs) in patients with atrial fibrillation (AF) in routine clinical practice …