Adenosine is released in the brain in significant quantities in response to increased cellular
activity. Adenosine has been shown either to decrease synaptic transmission or to produce …

Adenosine is a potent neuromodulator in the CNS, but the mechanisms that regulate
adenosine concentrations in the extracellular space remain unclear. The present study …

Adenosine is a potent modulator of neuronal activity throughout the nervous system.
Previous evidence suggests that adenosine presynaptically inhibits synaptic transmission …

Adenosine is a potent inhibitory modulator of synaptic transmission in the CNS, but its role in
normal physiological function is unclear. In the present experiments, we have found …

Extracellular and intracellular recordings from CA1 pyramidal neurones of rats in vitro were
used to study the effects of endogenous and exogenously applied adenosine. The …

1. The role of adenosine receptors in reducing calcium currents (ICa) and in triggering
presynaptic inhibition was studied using whole‐cell patch‐clamp techniques to record ICa …

Adenosine inhibits excitatory neurons widely in the brain through adenosine A1 receptor,
but activation of adenosine A2A receptor (A2AR) has an opposite effect promoting discharge …

In the hippocampus, the neuromodulatory role of adenosine depends on a balance between
inhibitory A1 responses and facilitatory A2A responses. Since the presynaptic effects of …

The purine nucleoside adenosine is released during seizure activity and exerts an
anticonvulsant influence through inhibition of glutamate release and hyperpolarization of …

Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …