Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like …

X Cheng, RCM Siow, GE Mann - Antioxidants & redox signaling, 2011 - liebertpub.com
Type 2 diabetes is an age-related disease associated with vascular pathologies, including
severe blindness, renal failure, atherosclerosis, and stroke. Reactive oxygen species (ROS) …

Redox sensitive transcription via Nrf2-Keap1 in suppression of inflammation

E Bhakkiyalakshmi, D Sireesh… - Immunity and Inflammation …, 2018 - Elsevier
Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism
characterized by hyperglycemia and results from insufficient insulin or an ineffective …

ROS acts as a double-edged sword in the pathogenesis of type 2 diabetes mellitus: is Nrf2 a potential target for the treatment?

X Wang, CX Hai - Mini reviews in medicinal chemistry, 2011 - ingentaconnect.com
Although the clear mechanism of T2DM is still to be elucidated, it has been well established
that reactive oxygen species (ROS) derived from multiple sources plays a causal role in …

[引用][C] Dysregulation of Nrf2 signaling in diabetes: An Opportunity for a multi-target approach

BP Dieter - J Diabetes Metab, 2014

Targeting the Nrf2 pathway against cardiovascular disease

J Li, T Ichikawa, JS Janicki, T Cui - Expert opinion on therapeutic …, 2009 - Taylor & Francis
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that controls the basal and
inducible expression of a battery of antioxidant genes and other cytoprotective Phase II …

[HTML][HTML] Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy

TI Adelusi, L Du, M Hao, X Zhou, Q Xuan, C Apu… - Biomedicine & …, 2020 - Elsevier
Hyperglycemia/oxidative stress has been implicated in the initiation and progression of
diabetic complications while the components of Keap1/Nrf2/ARE signaling are being …

Natural Nrf2 activators in diabetes

AS Jiménez-Osorio, S Gonzalez-Reyes… - Clinica chimica acta, 2015 - Elsevier
Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent
or delay diabetic complications that frequently result in increased morbidity and mortality …

The role of natural products in targeting cardiovascular diseases via Nrf2 pathway: novel molecular mechanisms and therapeutic approaches

BK Ooi, KG Chan, BH Goh, WH Yap - Frontiers in Pharmacology, 2018 - frontiersin.org
Cardiovascular diseases (CVDs) are closely linked to cellular oxidative stress and
inflammation. This may be resulted from the imbalance generation of reactive oxygen …

[HTML][HTML] Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: therapeutic targeting, challenges and future prospective

M Hashemi, MA Zandieh, S Ziaolhagh… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

NRF2-related epigenetic modifications in cardiac and vascular complications of diabetes mellitus

J Wang, M Xiao, J Wang, S Wang, J Zhang… - Frontiers in …, 2021 - frontiersin.org
Diabetes mellitus (DM) is a highly prevalent chronic disease that is accompanied with
serious complications, especially cardiac and vascular complications. Thus, there is an …