Novel strategies for inhibition of the p38 MAPK pathway

J Zhang, B Shen, A Lin - Trends in pharmacological sciences, 2007 - cell.com
The p38 subgroup of the mitogen-activated protein kinase superfamily has four isoforms:
p38α, p38β, p38δ and p38γ. Whereas p38α is involved in inflammation, proliferation …
被引用次数：202 相关文章 所有 8 个版本
[PDF] academia.edu

Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008

LH Pettus, RP Wurz - Current topics in medicinal chemistry, 2008 - ingentaconnect.com
The p38 mitogen-activated protein (MAP) kinase plays a central role in inflammation. It has
been the subject of extensive efforts in both basic research and drug discovery for the …
被引用次数：89 相关文章 所有 5 个版本

Map kinase p38inhibitors: Clinical results and an intimate look at their interactions with p38α protein

MR Lee, C Dominguez - Current medicinal chemistry, 2005 - ingentaconnect.com
Mitogen-activated protein kinase p38 is a serine/threonine kinase originally isolated from
lipopolysaccharide (LPS) stimulated monocytes. There are four isoforms p38α, p38β, p38γ …
被引用次数：283 相关文章 所有 7 个版本

The p38 MAPK inhibitors and their role in inflammatory diseases

TR Machado, TR Machado, PG Pascutti - ChemistrySelect, 2021 - Wiley Online Library
The p38 family is a highly evolutionarily conserved group of mitogen‐activated protein
kinases (MAPKs) that is involved in and helps co‐ordinate cellular responses to nearly all …
被引用次数：19 相关文章

p38 mitogen-activated protein kinase inhibitors—mechanisms and therapeutic potentials

JC Lee, S Kassis, S Kumar, A Badger… - Pharmacology & …, 1999 - Elsevier
The pyridinylimidazole compounds, exemplified by SB 203580, originally were prepared as
inflammatory cytokine synthesis inhibitors. Subsequently, the compounds were found to be …
被引用次数：495 相关文章 所有 6 个版本

p38 MAP kinase inhibitors: many are made, but few are chosen.

C Dominguez, DA Powers, N Tamayo - Current opinion in drug …, 2005 - europepmc.org
The mitogen-activated protein kinase (MAPK) p38 is a Ser/Thr kinase, originally isolated
from lipopolysaccharide-stimulated monocytes. There are four isoforms of the enzyme …
被引用次数：274 相关文章 所有 3 个版本
[PDF] academia.edu

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

S Kumar, J Boehm, JC Lee - Nature reviews Drug discovery, 2003 - nature.com
The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …
被引用次数：1553 相关文章 所有 12 个版本

The p38α kinase plays a central role in inflammation

GL Schieven - Current topics in medicinal chemistry, 2009 - ingentaconnect.com
The p38 kinase plays a central role in inflammation, and it has been the subject of extensive
efforts in both basic research and drug discovery. This review summarizes the biology of the …
被引用次数：130 相关文章 所有 4 个版本

The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer

HY Yong, MS Koh, A Moon - Expert opinion on investigational …, 2009 - Taylor & Francis
Background: The p38 mitogen-activated protein kinase (MAPK) is activated by various pro-
inflammatory and stressful stimuli. Mounting evidence suggests that the p38 MAPK signaling …
被引用次数：367 相关文章 所有 4 个版本
[PDF] academia.edu

Molecular basis for p38 protein kinase inhibitor specificity

JM Lisnock, A Tebben, B Frantz, EA O'Neill, G Croft… - Biochemistry, 1998 - ACS Publications
p38 is a member of the mitogen-activated protein (MAP) kinase family and is a critical
enzyme in the proinflammatory cytokine pathway. Other MAP kinase group members that …
被引用次数：157 相关文章 所有 6 个版本