INTRODUCTION The clinical manifestations of COVID-19 vary from asymptomatic infection
to respiratory failure. Severe disease courses are primarily associated with advanced age …

The identification of CD4+ T cell epitopes is instrumental for the design of subunit vaccines
for broad protection against coronaviruses. Here, we demonstrate in COVID-19–recovered …

Many unknowns exist about human immune responses to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have …

Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly
unfolding coronavirus disease 2019 (COVID-19) pandemic 1, 2. Clinical manifestations of …

INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …

Vaccine-induced CD8+ T cells are key to protection from SARS-CoV-2 | Nature Immunology Skip
to main content Thank you for visiting nature.com. You are using a browser version with limited …

Class II tetramer reagents for eleven common DR alleles and a DP allele prevalent in the
world population were used to identify SARS-CoV-2 CD4+ T cell epitopes. A total of 112, 28 …

CD4+ T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and
these are suggested to arise in response to common cold coronavirus (CCCoV) infection …

BACKGROUND Recent studies have reported T cell immunity to the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) in unexposed donors, possibly due to …