Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are
significantly upregulated and activated in many cancers and portend poor prognosis. Even …

Recent studies showed that Fatty Acid Synthase (FASN), a lipogenic enzyme overexpressed
in several carcinomas, plays an important role in drug resistance. Furthermore, the …

Obesity is a risk factor for triple‐negative breast cancer (TNBC) incidence and poor
outcomes, but the underlying molecular biology remains unknown. We previously identified …

The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer. CSC-
targeted therapies may prevent cancer relapse and provide more effective treatment. The …

Stable breast cancer cell (BCC) lines are valuable tools for the identification of breast cancer
stem cell (BCSC) phenotypes that develop in response to several stimuli as well as for …

Increased lipogenesis has been linked to an increased cancer risk and poor prognosis;
however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid …

Epidemiological studies have established a positive association between obesity and the
incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes …

According to the stem cell theory for cancer, hepatocellular carcinomas are sustained by a
group of cancer stem cells (CSCs) which are responsible for resistance to chemotherapy. In …

Cancers express high levels of fatty acid synthase (FAS) from which they derive fatty acids
for membrane biosynthesis to sustain cell proliferation. How cancer cells coordinate de novo …

Tumor growth and progression are linked to an altered lipid metabolism in the tumor
microenvironment (TME), including tumor cells and tumor-associated macrophages (TAMs) …