Fatty acid synthase (FAS), as a key enzyme involved in de novo lipogenesis, is highly
expressed in many cancers. FAS inhibition induces cell death in vivo and in vitro, rendering …

As a rate-limiting step in metastasis, metastatic colonization requires survival signals from
supportive stroma. However, the mechanisms driving this process are incompletely …

Cancer stem cells (CSCs) have recently been identified in leukaemia and solid tumours;
however, the role of CSCs in metastasis remains poorly understood. This dearth of …

Background Basal-like carcinoma are aggressive breast cancers that frequently carry p53
inactivating mutations, lack estrogen receptor-α (ERα) and express the cancer stem cell …

Background & aim Accumulated evidence indicates that the elevation of lipid metabolism is
an essential step in colorectal cancer (CRC) development, and analysis of the key lipogenic …

Background The function of preadipocytes in the progression of early stage breast cancer
has not been fully elucidated at the molecular level. To delineate the role of preadipocytes in …

The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer
progression remain to be fully understood. While altered glucose metabolism in CAFs could …

Background Enhanced macromolecule biosynthesis is integral to growth and proliferation of
cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer …

Cancer cells are defective in DNA repair, so they experience increased DNA strand breaks,
genome instability, gene mutagenesis, and tumorigenicity; however, multiple classic DNA …

Breast cancer stem cells (CSCs) are distinct CD44+-subpopulations that are involved in
metastasis and chemoresistance. However, the underlying molecular mechanism of CD44 …