Tight regulation of gene products from transcription to protein degradation is required for
reliable and robust control of eukaryotic cell physiology. Many of the mechanisms directing …

Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Allosteric regulatory processes are implicated at all levels of biological function. Recent
advances in our understanding of the diverse and functionally significant class of intrinsically …

Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since
their discovery, there are several aspects that remain unexplored and, hence, poorly …

Highlights•Protein disorder is highly over-represented within transcriptional
processes.•Protein disorder may accelerate binding, unbinding and/or DNA search …

The traditional structure to function paradigm conceives of a protein's function as emerging
from its structure. In recent years, it has been established that unstructured, intrinsically …

Virtually every process in a cell is carried out by macromolecular complexes whose actions
need to be perfectly orchestrated. The synchronization and regulation of these biological …

For proteins, the sequence→ structure→ function paradigm applies primarily to enzymes,
transmembrane proteins, and signaling domains. This paradigm is not universal, but rather …

Conformational flexibility conferred though regions of intrinsic structural disorder allows
proteins to behave as dynamic molecules. While it is well-known that intrinsically disordered …

Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …