The mechanisms underlying the ability of axons to regrow after injury remain poorly
explored at the molecular genetic level. We used a laser injury model in Caenorhabditis …

Highlights•Genetic screening reveals relevant molecules and expands molecular landscape
of axon regeneration.•In-depth mechanistic dissection uncovers signaling pathways.•In vivo …

Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual
green fluorescent protein‐labeled axons can be severed using laser microsurgery and their …

Axon injury triggers a series of changes in the axonal cytoskeleton that are prerequisites for
effective axon regeneration. In Caenorhabditis elegans the signaling protein Exchange …

Axons of adult Caenorhabditis elegans neurons undergo robust regenerative growth after
laser axotomy. Here we show that axotomy of PLM sensory neurons triggers axonal calcium …

Axons of the mammalian CNS lose the ability to regenerate soon after development due to
both an inhibitory CNS environment and the loss of cell-intrinsic factors necessary for …

The molecular and cellular mechanisms that allow adult-stage neurons to regenerate
following damage are poorly understood. Recently, axons of motoneurons and …

Regeneration of injured neurons can restore function, but most neurons regenerate poorly
or not at all. The failure to regenerate in some cases is due to a lack of activation of cell …

Functional neuronal recovery following injury arises when severed axons reconnect with
their targets. In Caenorhabditis elegans following laser‐induced axotomy, the axon still …

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …