Despite increasing knowledge about molecular pathways in pathogenesis of chronic liver
disease, selective therapeutic options are scarce, especially in advanced diseases …

Although chronic liver disease has many etiologies, including chronic viral hepatitis, alcohol
abuse, metabolic syndrome, and autoimmune disorders, the cellular and pathological …

Inflammation is one of the most characteristic features of chronic liver disease of viral,
alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease …

Inflammation has been shown to induce the progression of fibrosis in response to liver
injury. Among inflammatory cells, macrophages and lymphocytes play major roles in both …

Hepatic fibrosis represents as a dynamic pathological process characterized by the net
accumulation of extracellular matrix in the progression of various chronic liver diseases …

Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs
in a proinflammatory environment. However, the role of inflammatory mediators in fibrogenic …

Chemokines are a class of small chemotactic molecules with cytokine-like functions, which
are well known to orchestrate inflammatory responses within different organs. Overall, more …

The infiltration of various immune cell populations, including monocytes/macrophages,
natural killer (NK), NKT cells and T cells, is a central pathogenic feature following acute-and …

Liver fibrosis is associated with infiltrating immune cells and activation of hepatic stellate
cells. We here aimed to investigate the effects of the CC chemokine CCL3, also known as …

Liver fibrosis is a chronic disease characterized by the deposition of extracellular matrix and
continuous loss of tissues that perform liver functions. Macrophages are crucial modulators …