Inhibitors for galectin-1 and-3 were synthesized from thiodigalactoside and lactosamine by
derivatization of the galactose C3. Introduction of 4-phenyl-1 H-1, 2, 3-triazol-1-yl …

Symmetrical and asymmetrical fluorinated phenyltriazolyl-thiodigalactoside derivatives have
been synthesized and evaluated as inhibitors of galectin-1 and galectin-3. Systematic tuning …

A new series of orally available α-d-galactopyranosides with high affinity and specificity
toward galectin-1 have been discovered. High affinity and specificity were achieved by …

Galectin-3 is a member of a family of β-galactoside-binding proteins. A substantial body of
literature reports that galectin-3 plays important roles in cancer, inflammation, and fibrosis …

Combination of biophysical and structural techniques allowed characterizing and
uncovering the mechanisms underlying increased binding affinity of lactosamine derivatives …

Galectin inhibitors are urgently needed to understand the mode of action and druggability of
different galectins, but potent and selective agents still evade researchers. Small-sized …

Galectins are a family of carbohydrate recognition proteins involved in, among other things,
modulating cell signalling and cell–environment interactions, giving them roles in several …

Galactose C3-triazole derivatives were synthesized by Cu (I)-catalyzed cycloaddition
between acetylenes and galactose C3-azido derivatives. Evaluation against galectin-3, 7 …

A strategy for generating potential galectin inhibitors was devised based on derivatization at
the C‐3′ atom in 3′‐amino‐N‐acetyllactosamine by using structural knowledge of the …

Galectin-8 is a carbohydrate-binding protein that plays a crucial role in tumor progression
and metastasis, antibacterial autophagy, modulation of the immune system, and bone …