The non-peptide NK 2 receptor antagonist, GR159897, was evaluated in two putative
models of anxiety, the mouse light-dark box and the marmoset human intruder response …

Several neurotransmitters, including GABA, serotonin, glutamate, and cholecystokinin,
modulate defensive behaviors in the dorsolateral periaqueductal gray (dlPAG). Although …

The ability of the substance P (NK1 receptor) antagonist (SPA) L-760735 to inhibit
conditioned fear was assessed in gerbils using a four plate apparatus. Animals that had …

The present study was made to investigate the role of tachykinin NK2 receptors in the
expression of stress-related behaviors in animals. Under basal conditions, intraperitoneal …

Interest in central neurokinin (NK) 1 receptors has increased based on reports of the
therapeutic potential for NK1 antagonists in anxiety and depression. In these studies, an ex …

WE reported previously that the neurokinin substance P has anxiolytic-like effects when
administered into the nucleus basalis of the rat ventral pallidum. The present study aimed to …

Brain neuropeptide transmitters of the tachykinin family are involved in the organization of
many behaviors. However, little is known about their contribution to the behavioral effects of …

Substance P (SP) and neurokinin A (NKA) encoded by the preprotachykinin A (TAC1) gene
have been evidenced to play an important role in psychiatric disorders including anxiety and …

The neuropsychopharmacological basis of fear‐or panic‐related behavior has been the
focus of several studies. Some mesencephalic tectum (MT) structures, such as the superior …

This study investigated the effectiveness of ketamine, a noncompetitive N-methyl-d-
aspartate (NMDA) receptor antagonist, in alleviating the enhanced anxiety and fear …