Overall survival of patients with newly diagnosed glioblastoma (GBM) remains dismal at 16
months with state-of-the-art treatment that includes surgical resection, radiation, and …

Among central nervous system tumors, Glioblastoma (GBM) is the most common, aggressive
and neurological destructive primary brain tumor in adults. Standard care therapy for GBM …

Successful treatment of glioblastoma (GBM) is hampered by primary tumor recurrence after
surgical resection and poor prognosis, despite adjuvant radiotherapy and chemotherapy. In …

Glioblastoma is the most frequent primary malignant brain tumor in adults. Despite
treatments including surgery, radiotherapy and chemotherapy by oral Temozolomide (TMZ) …

Introduction We have completed in vivo safety and efficacy studies of the use of a novel drug
delivery system, a gel matrix-temozolomide formulation that is injected intracranially into the …

Purpose. To evaluate the feasibility of regional radiochemotherapy of mammary tumors
using in situ hydrogel loaded with cisplatin (CDDP) and rhenium-188 (188 Re). Methods …

Glioblastoma (GBM) treatment includes, when possible, surgical resection of the tumor
followed by radiotherapy and oral chemotherapy with temozolomide, however recurrences …

Highlights•Hydrogel-based drug delivery systems can be more efficacious than the systemic
therapies.•They provide a high concentration and a sustained release of the drugs at tumor …

Cancer treatment is still one of most researched fields in biomedical science. The serious
side effects of intravenous chemotherapy have prompted the development of drug carriers …

Background Carboplatin, an antineoplastic agent, binds DNA and enhances radiotherapy
(RT) effects. Carboplatin-loaded hydrogel (oxidized hyaluronic acid/adipic acid dihydrazide) …