N-substituted benztropine (BZT) analogs are molecules that display high affinity for the
dopamine transporter (DAT), therapeutic-like effects in animal models of cocaine abuse, and …

Benztropine (BZT) analogs, a family of high-affinity dopamine transporter ligands, are
molecules that exhibit pharmacological and behavioral characteristics predictive of …

Rationale N-substituted benztropine analogs are potent dopamine uptake inhibitors that
display pharmacokinetic/dynamic properties consistent with the profile of a substitute …

An N-butyl analog of benztropine, JHW007 [N-(n-butyl)-3 α-[bis (4′-fluorophenyl) methoxy]-
tropane], binds to dopamine transporters (DAT) but has reduced cocaine-like behavioral …

The benztropine analog N-(n-butyl)-3α-[bis (4′-fluorophenyl) methoxy]-tropane (JHW 007)
displays high affinity for the dopamine transporter (DAT), but unlike typical DAT ligands, has …

Benztropine (BZT) analogs, a family of agents with high affinity for the dopamine transporter
have been postulated as potential treatments in stimulant abuse due to their ability to …

Previous studies demonstrated that analogs of benztropine (BZT) possess high affinity for
the dopamine transporter, inhibit dopamine uptake, but generally have behavioral effects …

The discovery and evaluation of high affinity dopamine transport inhibitors with low abuse
liability is an important step toward the development of efficacious medications for cocaine …

Rationale: Previous SAR studies demonstrated that small halogen substitutions on the
diphenylether system of benztropine (BZT), such as a para-Cl group, retained high affinity at …

Several studies suggest that a dopamine transporter uptake inhibitor that has a slower onset
and longer duration of action than cocaine in animal behavioral measures and decreases …