Challenges in quantifying cytosine methylation in the HIV provirus
ABSTRACT DNA methylation is an epigenetic mechanism most commonly associated with
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …
[HTML][HTML] Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals
Background The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the
promoter and intragenic regions. DNA methylation in the promoter region has been shown …
promoter and intragenic regions. DNA methylation in the promoter region has been shown …
[HTML][HTML] Deciphering DNA methylation in HIV infection
T Arumugam, U Ramphal, T Adimulam… - Frontiers in …, 2021 - frontiersin.org
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …
new global infections per year, it is imperative that we advance our understanding of all …
In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus
L Chávez, S Kauder, E Verdin - Methods, 2011 - Elsevier
HIV-1 latency is a barrier to overcome in the effort to fully eradicate the virus from infected
individuals using highly active anti-retroviral therapy (HAART). Therefore, the study of the …
individuals using highly active anti-retroviral therapy (HAART). Therefore, the study of the …
[HTML][HTML] Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response
DNA methylation is one of the epigenetic modifications that configures gene transcription
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
[HTML][HTML] Development of 5 'LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals
K Trejbalová, D Kovářová, J Blažková, L Machala… - Clinical …, 2016 - Springer
Background Human immunodeficiency virus type 1 (HIV-1) latency represents the major
barrier to virus eradication in infected individuals because cells harboring latent HIV-1 …
barrier to virus eradication in infected individuals because cells harboring latent HIV-1 …
HIV infection alters the human epigenetic landscape
Many complex diseases or traits are the results of both genetic and environmental factors.
The environmental factors affect the human body by modifying its epigenetics, which …
The environmental factors affect the human body by modifying its epigenetics, which …
[HTML][HTML] Epigenetic regulation of HIV-1 latency by cytosine methylation
SE Kauder, A Bosque, A Lindqvist, V Planelles… - PLoS …, 2009 - journals.plos.org
Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T
cells of infected persons treated with highly active antiretroviral therapy (HAART). This …
cells of infected persons treated with highly active antiretroviral therapy (HAART). This …
[HTML][HTML] CpG methylation controls reactivation of HIV from latency
J Blazkova, K Trejbalova, F Gondois-Rey, H Philippe… - Retrovirology, 2010 - Springer
Background DNA methylation of retroviral promoter and enhancer localized in the provirus
5'long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression …
5'long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression …