Centrosomal dynactin is required for normal microtubule anchoring and/or focusing
independently of dynein. Dynactin is present at centrosomes throughout interphase, but …

Mitotic spindles in epithelial cells are oriented in the plane of the epithelium so that both
daughter cells remain within the monolayer, and defects in spindle orientation have been …

The orientation of cell division along the long axis of the interphase cell—the century-old
Hertwig's rule—has profound roles in tissue proliferation, morphogenesis, architecture and …

In model organisms, resistance to inhibitors of cholinesterase 8 (Ric-8), a G protein α (Gα)
subunit guanine nucleotide exchange factor (GEF), functions to orient mitotic spindles during …

Polarized epithelia form by oriented cell divisions in which the mitotic spindle aligns parallel
to the epithelial plane. To orient the mitotic spindle, cortical cues trigger the recruitment of …

Correct positioning of the mitotic spindle is critical to establish the correct cell-division plane.
Spindle positioning involves capture of astral microtubules and generation of …

During cell division metaphase spindles maintain constant length, whereas spindle
microtubules continuously flux polewards, requiring addition of tubulin subunits at …

The spindle apparatus dictates the plane of cell cleavage, which is critical in the choice
between symmetric or asymmetric division. Spindle positioning is controlled by an …

To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We
know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized …

Microtubules participate in a wide variety of cellular functions such as the maintenance of
cell shape, particle and organelle movements, the separation of chromosomes on the mitotic …