Objectives: To determine whether excess weight is associated with antibiotic treatment
failure (ATF) and if this may be due to a lack of weight-based dosing. Methods: Using a …

Antibiotic dosage optimization in special population groups is a desirable task in clinical
practice since product label recommendations rely on drug information from a reduced …

Aminoglycosides are an important class of agents that are used in combination antimicrobial
regimens to treat bacterial pathogens. Dosing of aminoglycosides is typically based on total …

Background and Importance Information regarding the impact of obesity on the
pharmacokinetics of most drugs is limited. Obesity is associated with physiopathological …

Background: Imipenem is a broad-spectrum β-lactam antibiotic frequently used for infectious
complications in ICU patients. Dosing optimisation still remains challenging for clinicians …

Obese patients may be at a greater risk for acute kidney injury (AKI) with the use of certain
antimicrobial agents that are dosed by weight. Current preclinical models of AKI utilize the …

With Demystifying Drug Dosing in Obese Patients, that resource you need is here,
delivering: Fully-referenced dosing recommendations for specific drugs Dedicated chapters …

Purpose The goal of this review is to explore the role of antimicrobial therapeutic drug
monitoring (TDM), especially in critically ill, obese, and older adults, with a specific focus on …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

The impact of adjusted treatment on clinical outcomes in patients with severe obesity is
unclear. This study included adults with severe obesity admitted for bloodstream infections …