Novel evidence for m6A methylation regulators as prognostic biomarkers and potential therapeutic targets in gastric cancer
Abstract Purpose: N6-methyladenosine (m6A) post-transcriptional RNA modification
represents the most abundant epigenetic alteration in eukaryotic cells. These m6A …
represents the most abundant epigenetic alteration in eukaryotic cells. These m6A …
Novel evidence for m6A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer
T Shimura, R Kandimalla, Y Okugawa, M Ohi… - British journal of …, 2022 - nature.com
Background While emerging evidence indicates that N 6-methyladenosine (m6A) regulators
play crucial roles in cancer progression, their clinical significance in gastric cancer (GC) has …
play crucial roles in cancer progression, their clinical significance in gastric cancer (GC) has …
Dysregulation of m6A RNA methylation regulators in colorectal cancer: clinical implication as prognostic biomarkers and potential therapeutic targets
R Kandimalla, F Gao, C Ruan, M Hsieh, X Wang… - Cancer Research, 2018 - AACR
Purpose Among more than 100 known post-transcriptional modifications, N6-
Methyladenosine (m6A) represents the most prevalent internal modification in mammalian …
Methyladenosine (m6A) represents the most prevalent internal modification in mammalian …
[HTML][HTML] N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
B Hu, X Wang, XY Gu, C Zou, Z Gao, H Zhang, Y Fan - Molecular cancer, 2019 - Springer
Analogous to DNA methylation and histone modification, RNA modification, as another
epigenetic layer, plays an important role in many diseases, especially in tumours. As the …
epigenetic layer, plays an important role in many diseases, especially in tumours. As the …
[HTML][HTML] Role of N6-methyladenosine RNA modification in gastric cancer
SQ Ding, XP Zhang, JP Pei, X Bai, JJ Ma… - Cell Death …, 2023 - nature.com
Abstract N6-methyladenosine (m6A) RNA methylation is the most prevalent internal
modification of mammalian messenger RNA. The m6A modification affects multiple aspects …
modification of mammalian messenger RNA. The m6A modification affects multiple aspects …
FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner
Z Yin, X Guo, X Liang, Z Wang - Medical Oncology, 2024 - Springer
Gastric cancer (GC) is a serious malignant tumour with a high mortality rate and a poor
prognosis. Recently, emerging evidence has suggested that N6-methyladenosine (m6A) …
prognosis. Recently, emerging evidence has suggested that N6-methyladenosine (m6A) …
[HTML][HTML] Function and clinical significance of N6-methyladenosine in digestive system tumours
J Huang, Y Shao, W Gu - Experimental hematology & oncology, 2021 - Springer
RNA modification, like DNA methylation, histone modification, non-coding RNA modification
and chromatin rearrangement, plays an important role in tumours. N6-methyladenosine …
and chromatin rearrangement, plays an important role in tumours. N6-methyladenosine …
[HTML][HTML] Mechanisms and clinical landscape of N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers
DH Zhu, KK Su, XX Ou-Yang, YH Zhang, XP Yu… - Molecular and Cellular …, 2024 - Springer
Epigenetics encompasses reversible and heritable chemical modifications of non-nuclear
DNA sequences, including DNA and RNA methylation, histone modifications, non-coding …
DNA sequences, including DNA and RNA methylation, histone modifications, non-coding …
[HTML][HTML] The potential role of RNA N6-methyladenosine in Cancer progression
T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …
[HTML][HTML] N6-methylation in the development, diagnosis, and treatment of gastric cancer
J Wang, G Zhao, Y Zhao, Z Zhao, S Yang… - Journal of …, 2024 - degruyter.com
Gastric cancer (GC) ranks third among cancers in terms of mortality rate worldwide. A clear
understanding of the mechanisms underlying the genesis and progression of GC will …
understanding of the mechanisms underlying the genesis and progression of GC will …