Although the calcium-sensing receptor (CaSR) is expressed by all types of nerve cells in
widespread areas of the human central nervous system (CNS), so far its roles in brain …

It is generally assumed that the neuropathology of sporadic (late-onset or nonfamilial)
Alzheimer's disease (AD) is driven by the overproduction and spreading of first Amyloid-βx …

Alzheimer's disease (AD) is the most common human neurodegenerative ailment, the most
prevalent (> 95%) late-onset type of which has a still uncertain etiology. The progressive …

In aged subjects, late-onset Alzheimer's disease (LOAD) starts in the lateral entorhinal
allocortex where a failure of clearance mechanisms triggers an accumulation of neurotoxic …

The Calcium-Sensing Receptor (CaSR) is a G-protein coupled, 7-transmembrane domain
receptor ubiquitously expressed throughout the body, brain including. The role of CaSR in …

Calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCRs). Soluble β-
amyloid peptide (Aβ) is one of the orthosteric modulators of CaSR, while, the role and …

Available evidence shows that human cortical neurons' and astrocytes' calcium-sensing
receptors (CaSRs) bind Amyloid-beta (Aβ) oligomers triggering the overproduction …

Astrocytes' roles in late-onset Alzheimer's disease (LOAD) promotion are important, since
they survive soluble or fibrillar amyloid-β peptides (Aβs) neurotoxic effects, undergo …

Fibrillar aggregates and soluble oligomers of both Amyloid-β peptides (Aβs) and
hyperphosphorylated Tau proteins (p-Tau-es), as well as a chronic neuroinflammation are …

Dysregulation in calcium signaling pathways plays a major role in the initiation of
Alzheimer's disease (AD) pathogenesis. Accumulative experimental evidence obtained with …