Amiodarone is an effective class III antiarrhythmic drug, however, the pulmonary toxicity is
one of the most life-threatening complications of its use. The present study was designed to …

Amiodarone-induced pulmonary toxicity is a serious side-effect, but the underlying
molecular mechanisms remain unclear. We examined phospholipidosis and apoptosis in rat …

Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM …

The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …

To investigate whether amiodarone induces apoptosis in cells of the L-132 human lung
epithelial cell line, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay …

Amiodarone, bi-iodinated benzofuran derivative, is one of the most frequently prescribed
and efficacious antiarrhythmic drugs. Despite its low incidence, amiodarone-induced …

Amiodarone (AM), a potent antidysrhythmic agent, can cause potentially life-threatening
pulmonary fibrosis. In the present investigation of mechanisms of initiation of AM lung …

Background: The clinical usefulness of amiodarone for the treatment of cardiac arrhythmias
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. We previously reported a model …

Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-
threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may …