Amiodarone (AMD) is one of the most effective antiarrhythmic drugs available. However, its
use is often limited by side-effects, mainly hypo-or hyperthyroidism. As AMD displays direct …

Amiodarone is a potent antidysrhythmic drug that is associated with severe pulmonary
toxicity. The mechanism of amiodarone pulmonary toxicity is poorly understood. To …

Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …

Amiodarone (AM) is a potent and efficacious antidysrhythmic agent that can cause
potentially life-threatening pulmonary fibrosis. Vitamin E has been demonstrated to …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …

Amiodarone (AMI) is a potent antiarrhythmic agent; however, its clinical use is limited due to
numerous side effects. In order to investigate the structure–cytotoxicity relationship, AMI …

BACKGROUND: Although amiodarone is a potent antiarrhythmic agent, its clinical use is
limited by serious lung toxicity. This study investigated the mechanisms of amiodarone …

Objective This study was undertaken to investigate the effect of long-term amiodarone
administration and withdrawal on the histological structure of rat lung. In addition, the …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …

Amiodarone can cause pulmonary toxicity along with an increase in phospholipid in
macrophages, lymphocytes, and other cell types. Phospholipid accumulates because …