Several lines of evidence suggest that the cyclooxygenase enzymes (specifically COX-2)
might be an important molecular target for the intervention of cancer at both early and late …

By inhibiting the cyclooxygenase (COX) enzyme, NSAIDs block the synthesis of
prostaglandins, which are important mediators of multiple physiologic and pathophysiologic …

Multiple lines of evidence suggest that aberrant induction and upregulation of the
prostaglandin cascade play a significant role in colon and mammary carcinogenesis, and …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

The cyclo-oxygenase (COX) metabolic pathway and prostaglandin (PG) production appear
to play a causal role in the promotion and progression of human cancers. COX-1 and COX-2 …

Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has
attracted considerable attention recently, due to its role in human cancer biology. Several …

Carcinogenesis is a multistep process of long-term accumulation of genetic and epigenetic
aberrations at the molecular level. Understanding the mechanisms underlying …

Prostaglandin synthesis by a number of enzymes is important at all stages during the
genesis of cancer. The availability of prostaglandin H2 as a substrate for prostaglandin …

Cyclooxygenase (COX), and specifically COX-2, may be an important molecular target for
cancer prevention. Initial support for this hypothesis comes from several lines of evidence …

Prior to the discovery of cyclooxygenase-2 (COX-2), a beneficial association was shown
between chronic usage of non steroidal anti-inflammatory drugs (NSAIDs), that …