Following the “finished,” euchromatic, haploid human reference genome sequence, the
rapid development of novel, faster, and cheaper sequencing technologies is making …

The completion of draft sequences of the human genome represented a remarkable
achievement for automated DNA sequencing based on Sanger technology. However, the …

Genomic sequencing has undergone massive expansion in the past 10 yr, from a rarely
used research tool into an approach that has broad applications in a clinical setting. From …

Next-generation sequencing technologies have greatly lowered the cost of whole-genome
sequencing (WGS) and related approaches. Thus, comprehensive sequencing for …

Substantial progress has been made in human genetics and genomics research over the
past ten years since the publication of the draft sequence of the human genome in 2001 …

Technological advances often outpace our ability to effec-tively use them, a situation that
certainly could pertain to modern genomics. Breathtaking advances in genetic sequencing …

The price of whole-genome and-exome sequencing has fallen to the point where these
methods can be applied to clinical medicine. Here, we outline the lessons we have learned …

Clinical researchers, practicing physicians, patients, and the general public now live in a
world in which the 2.9 billion nucleotide codes of the human genome are available as a …

The revolution in DNA sequencing technologies has now made it feasible to determine the
genome sequences of many individuals; ie,“personal genomes.” Genome sequences of …

The reference human genome provides an adequate basis for biological researchers to
study the relationship between genotype and the associated phenotypes, but a large push is …