We consider cancer chemotherapy as an optimal control problem with the aim to minimize a
combination of the tumor volume and side effects over an a priori specified therapy horizon …

The mathematical study of cancer received great attention in recent years. The theoretical
and numerical investigations of models employed for studying the growth of cancer cells and …

We investigate a model of a cancer chemotherapy problem where the aim is to minimize the
tumor burden at the end of the treatment period while maintaining a normal cell population …

A mathematical model of tumor cell population dynamics is considered. The tumor is
assumed to consist of cells of two types: amenable and resistant to chemotherapeutic …

A mathematical model for cancer chemotherapy of heterogeneous tumor populations is
considered as an optimal control problem with the objective to minimize the tumor burden …

A 3-compartment model for metronomic chemotherapy that takes into account cancerous
cells, the tumor vasculature and tumor immune-system interactions is considered as an …

A nonautonomous mathematical model of chemotherapy cancer treatment with time-
dependent infusion concentration of the chemotherapy agent is developed and studied. In …

In this paper, a mathematical model for chemotherapy that takes tumor immune-system
interactions into account is considered for a strongly targeted agent. We use a classical …

In this paper, we study a dynamic optimization problem for a general nonlinear mathematical
model for therapy of a lethal form of cancer. The model describes how the populations of …

In this manuscript, we shall apply the tools and methods from optimal control to analyze
various minimally parameterized models that describe the dynamics of populations of …