In order to understand the biological importance of naturally occurring sialic acid variations
on disialyl structures in nature, we developed an efficient two-step multienzyme approach for …

Conspectus Sialic acids are fascinating negatively charged nine-carbon monosaccharides.
Sialic acid-containing glycans and glycoconjugates are structurally diverse, functionally …

Sialic acids are a family of negatively charged monosaccharides which are commonly
presented as the terminal residues in glycans of the glycoconjugates on eukaryotic cell …

Highlights•Chemical synthesis provided access to O-linked and S-linked oligosialic
acids.•Oxazolidinone-protected sialyl donors enable α-selective sialylation.•Enzymatic …

The substrate specificity and enzymatic sialylation ability of the bacterium α-2, 6-
sialyltransferase were examined. The enzyme assay displayed a remarkable ability to …

Sialic acids on the non-reducing terminus of sialylgylcans are abundantly expressed on the
surface of mammalian cells. They play vital roles in cell-cell interactions and during infection …

Sialic acid‐containing glycans play important roles in biology, but their synthesis by
standard chemical approaches is challenging. Enzymatic assembly is generally a better …

Naturally occurring 8-O-methylated sialic acids, including 8-O-methyl-N-acetylneuraminic
acid and 8-O-methyl-N-glycolylneuraminic acid, along with 8-O-methyl-2-keto-3-deoxy-d …

Sialic acids are important recognition sites in protein-and lipid-linked glycans of higher
organisms and of select bacteria and protozoa. They are also prominent in human milk …

Modifications at the glycerol side chain of sialic acid in sialosides modulate their recognition
by sialic acid-binding proteins and sialidases. However, limited work has been focused on …