The complement system consists of a tightly regulated network of proteins that play an
important role in host defense and inflammation. Complement activation results in …

The complement system is a component of the innate immune system. Its main function was
initially believed to be limited to the recognition and elimination of pathogens through direct …

Our understanding of the biology of the complement system has undergone a drastic
metamorphosis since its original discovery. This system, which was traditionally primarily …

Complement is traditionally known to be a system of serum proteins that provide protection
against pathogens through direct cell lysis and the mobilization of innate and adaptive …

Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …

The complement system is an important part of the innate immune defense. Next to its role
as an effector mechanism of the innate immune system, complement also plays a major role …

Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …

Since its discovery in the 19th century, the complement system has developed into a
clinically significant entity. The complement system has been implicated in a variety of …

The complement system has vital protective functions as a humoral component of the innate
immune system and also through interactions with the adaptive immune system; however …

The complement system is important for cellular integrity and tissue homeostasis.
Complement activation mediates the removal of microorganisms and the clearance of …