Frontier studies on natural products: Moving toward paradigm shifts

JX Zhao, JM Yue - Science China Chemistry, 2023 - Springer
Natural products (NPs) historically serve as a valuable and productive source of bioactive
compounds for drug development. The discovery of a range of alkaloids in the early 1800s …

The re-emergence of natural products for drug discovery in the genomics era

AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Natural products for human health: an historical overview of the drug discovery approaches

S Bernardini, A Tiezzi, V Laghezza Masci… - Natural product …, 2018 - Taylor & Francis
Natural products (NPs) are secondary metabolites produced and used by organisms for
defending or adapting purposes. These molecules were naturally selected during thousands …

[HTML][HTML] Progress and impact of Latin American natural product databases

A Gómez-García, JL Medina-Franco - Biomolecules, 2022 - mdpi.com
Natural products (NPs) are a rich source of structurally novel molecules, and the chemical
space they encompass is far from being fully explored. Over history, NPs have represented a …

[图书][B] Natural product chemistry for drug discovery

AD Buss, MS Butler - 2010 - books.google.com
Page 1 RSC Biomolecular Sciences Edited by Antony D Buss and Mark S Butler Natural Product
Chemistry for Drug Discovery HOC HO 0= NH 0= HOC HN FO HN Q= HO₂C OH H₂NOC Fo …

Strategies to diversify natural products for drug discovery

G Li, HX Lou - Medicinal research reviews, 2018 - Wiley Online Library
Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

[PDF][PDF] Recent natural products based drug development: a pharmaceutical industry perspective

YZ Shu - Journal of natural products, 1998 - chem.uwec.edu
The search for new pharmacologically active agents obtained by screening natural sources
such as microbial fermentations and plant extracts has led to the discovery of many clinically …

The impact and prospect of natural product discovery in agriculture: New technologies to explore the diversity of secondary metabolites in plants and microorganisms …

Y Yan, Q Liu, SE Jacobsen, Y Tang - EMBO reports, 2018 - embopress.org
Natural products (NPs) are small organic molecules of< 1,500 Da that are produced mostly
by microorganisms and plants, and many of them have enormously benefited human health …

Industrial natural product chemistry for drug discovery and development

A Bauer, M Brönstrup - Natural product reports, 2014 - pubs.rsc.org
Covering: up to March 2013 In addition to their prominent role in basic biological and
chemical research, natural products are a rich source of commercial products for the …

Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery

M Grigalunas, A Burhop, A Christoforow… - Current Opinion in …, 2020 - Elsevier
Through evolution, nature has provided natural products (NPs) as a rich source of diverse
bioactive material. Many drug discovery programs have used nature as an inspiration for the …