Background: Evidence indicates that neuropathic pain pathogenesis is not confined to
changes in the activity of neuronal systems but involves interactions between neurons …

Neuropathic pain occurs after peripheral nerve damage, inflammation or infection. In this
situation, microglial cells become activated and play a key role in producing pain …

Inflammatory mediators produced in the injured nerve have been proposed as contributing
factors in the development of neuropathic pain. In this regard an important role is assigned …

Objective (s): Several lines of evidence showed that minocycline possesses antioxidant and
anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in …

Recent research has shown that microglial cells which are strongly activated in neuropathy
can influence development of allodynia and hyperalgesia. Here we demonstrated that …

It is confirmed that pharmacological attenuation of glial cells can alleviate neuropathic pain
by lowering proinflammatory cytokine expression. The present study tries to confirm that post …

A single streptozotocin (STZ) injection in mice can induce significant neuropathic pain along
with an increase in plasma glucose levels and a decrease in body weight. Seven days after …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …

In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein
expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline …

It has been demonstrated that spinal microglial activation is involved in formalin-induced
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …