The toxin-coregulated pilus (TCP) is one of the major virulence factors of Vibrio cholerae.
Biogenesis of this type 4 pilus (Tfp) requires a number of structural components encoded by …

The Type II Secretion System (T2SS) is a molecular machine that drives the secretion of fully-
folded protein substrates across the bacterial outer membrane. A key element in the …

Typical enteropathogenic Escherichia coli strains express an established virulence factor
belonging to the type IV pili family, called the bundle-forming pilus (BFP). BFP are present …

Colonization of the human small intestine by Vibrio cholerae requires the type 4 toxin co‐
regulated pilus (TCP). Genes encoding the structure and biogenesis functions of TCP are …

The type II secretion system (T2SS) exports folded proteins from the periplasms of Gram‐
negative bacteria. The type IV pilus system (T4PS) is a multifunctional machine used for …

The type II secretion pathway of Pseudomonas aeruginosa is involved in the extracellular
release of various toxins and hydrolytic enzymes such as exotoxin A and elastase. This …

Production of type IV bundle-forming pili by enteropathogenic Escherichia coli (EPEC)
requires BfpB, an outer-membrane lipoprotein and member of the secretin protein …

The bacterial type II protein secretion (T2S) and type IV piliation (T4P) systems share several
common features. In particular, it is well established that the T2S system requires the …

Pseudomonas aeruginosa type IV pili (T4P) are virulence factors that promote infection of
cystic fibrosis and immunosuppressed patients. As the absence of T4P impairs colonization …

PilT is a hexameric ATPase required for type IV pilus retraction in gram-negative bacteria.
Retraction of type IV pili mediates intimate attachment to and signaling in host cells, surface …