ABSTRACT Type IV pili (T4P) are retractile appendages that contribute to the virulence of
bacterial pathogens. PilF is a Pseudomonas aeruginosa lipoprotein that is essential for T4P …

Vibrio cholerae is the etiological agent of the acute intestinal disorder cholera. The toxin-
coregulated pilus (TCP), a type IVb pilus, is an essential virulence factor of V. cholerae …

Pseudomonas aeruginosa uses type IV pili (T4P) to interact with the environment and as key
virulence factors when acting as an opportunistic pathogen. Assembly of the outer …

The Vibrio cholerae genome contains a 5.4-kb pil gene cluster that resembles the
Aeromonas hydrophila tap gene cluster and other type IV-A pilus assembly operons. The …

Biogenesis of a superfamily of surface structures by gram-negative bacteria requires the
chaperone/usher pathway, a terminal branch of the general secretory pathway. In this …

The type 2 secretion system (T2SS) occurring in Gram-negative bacteria is composed of 12–
15 different proteins which form large assemblies spanning two membranes and secreting …

The secreton or type II secretion machinery of gram-negative bacteria includes several type
IV pilin-like proteins (the pseudopilins) that are absolutely required for secretion. We …

EpsE is an ATPase that powers transport of cholera toxin and hydrolytic enzymes through
the Type II secretion (T2S) apparatus in the Gram-negative bacterium, Vibrio cholerae. On …

Type IV pilus (T4P) systems are complex molecular machines that polymerize major pilin
proteins into thin filaments displayed on bacterial surfaces. Pilus functions require rapid …

Gram-negative bacteria assemble a variety of adhesive organelles on their surface,
including the thread-like structures known as pili. Recent studies on pilus assembly by the …