Many Gram-negative bacteria secrete specific proteins via the type II secretion systems
(T2SS). These complex machineries share with the related archaeal flagella and type IV …

Type IV pili (Tfps) are filamentous surface appendages expressed by Gram‐negative
microorganisms and play numerous roles in bacterial cell biology. Tfp biogenesis …

The chaperone/usher (CU) pathway is a conserved bacterial secretion system that
assembles adhesive fibres termed pili or fimbriae. Pilus biogenesis by the CU pathway …

Vibrio cholerae causes diarrheal disease through colonization of the small intestine. A
critical aspect of V. cholerae pathogenesis is its ability to actively secrete cholera toxin to the …

Summary Type IV pili (T4P) are critical to virulence for Vibrio cholerae and other bacterial
pathogens. Among their diverse functions, T4P mediate microcolony formation, which …

Gram-negative bacteria have evolved diverse secretion systems/machineries to translocate
substrates across the cell envelope. These various machineries fulfil a wide variety of …

The biogenesis of most types of bacterial pili requires two specialized proteins: a chaperone
that caps the pilus subunits in the periplasm, and an outer membrane usher that receives the …

Secretion systems are specialized in transport of proteins, DNA or nutrients across the cell
envelope of bacteria and enable them to communicate with their environment. The …

Cholera toxin secretion is dependent upon the extracellular protein secretion apparatus
encoded by the eps gene locus of Vibrio cholerae. Although the eps gene locus encodes …

Vibrio cholerae O1 expresses a pilus that is coordinately regulated with cholera toxin
production and hence termed TCP, for toxin-coregulated pilus. Insertion of Tn5 IS50L:: phoA …