Mucosal [SIgA] and serum [IgG] immunologic responses in the community after a single intra-nasal immunization with a new inactivated trivalent influenza vaccine

E Greenbaum, A Furst, A Kiderman, B Stewart, R Levy… - Vaccine, 2002 - Elsevier
Influenza morbidity affects entire populations, imposing an enormous burden in economic
terms from working days lost. Protection afforded by current vaccines is often unsatisfactory …

Mucosal (SIgA) and serum (IgG) immunologic responses in young adults following intranasal administration of one or two doses of inactivated, trivalent anti-influenza …

E Greenbaum, D Engelhard, R Levy, M Schlezinger… - Vaccine, 2004 - Elsevier
Influenza morbidity affects the entire population and has an enormous impact upon the
economic burden and the health care systems. Available vaccines are often unsatisfactory …

Localized mucosal response to intranasal live attenuated influenza vaccine in adults

MI Barría, JL Garrido, C Stein, E Scher… - The Journal of …, 2013 - academic.oup.com
Background. Influenza virus infection is a major public health burden worldwide. Available
vaccines include the inactivated intramuscular trivalent vaccine and, more recently, an …

A dose–response evaluation of inactivated influenza vaccine given intranasally and intramuscularly to healthy young adults

RL Atmar, WA Keitel, TR Cate, FM Munoz, F Ruben… - Vaccine, 2007 - Elsevier
Epidemic influenza occurs annually throughout the world and is accompanied by excess
morbidity and mortality. Increasing the antigen content and topical administration of vaccine …

Human immune responses elicited by an intranasal inactivated H5 influenza vaccine

A Ainai, E van Riet, R Ito, K Ikeda… - Microbiology and …, 2020 - Wiley Online Library
Intranasally administered influenza vaccines could be more effective than injected vaccines,
because intranasal vaccination can induce virus‐specific immunoglobulin A (IgA) antibodies …

Safety and immunogenicity of adjuvanted and unadjuvanted subunit influenza vaccines administered intranasally to healthy adults

TG Boyce, HH Hsu, EC Sannella… - Vaccine, 2000 - Elsevier
Antigen-specific mucosal immunity is thought to be important for protection against influenza
virus infection. Currently licensed parenteral influenza vaccines stimulate the production of …

Serum and mucosal immunologic responses in children following the administration of a new inactivated intranasal anti‐influenza vaccine

E Greenbaum, A Furst, A Kiderman… - Journal of medical …, 2001 - Wiley Online Library
Children are at considerable risk for influenza infection and may constitute the main vector
for transmitting the virus to adults in the community. At present, the use of available vaccines …

Intranasal vaccination with an inactivated whole influenza virus vaccine induces strong antibody responses in serum and nasal mucus of healthy adults

A Ainai, S Tamura, T Suzuki, E van Riet… - Human vaccines & …, 2013 - Taylor & Francis
Haemagglutination inhibition (HI) and neutralization (NT) titers as well as haemagglutinin
(HA) specific antibody responses were examined in 50 healthy adults aged between 22 and …

Local and systemic influenza haemagglutinin-specific antibody responses following aerosol and subcutaneous administration of inactivated split influenza vaccine

Y Oh, K Ohta, H Kuno-Sakai, R Kim, M Kimura - Vaccine, 1992 - Elsevier
An easily administered and safe vaccine is required to produce the herd immunity necessary
to control influenza epidemics worldwide. A commercial quadrivalent inactivated split …

Nasal IgA provides protection against human influenza challenge in volunteers with low serum influenza antibody titre

VMW Gould, JN Francis, KJ Anderson… - Frontiers in …, 2017 - frontiersin.org
In spite of there being a number of vaccines, influenza remains a significant global cause of
morbidity and mortality. Understanding more about natural and vaccine induced immune …