To obtain insight into the structure− activity relationships of new antitumor active platinum
compounds the X-ray structure of the antitumor active Pt compound [Pt (bmic) Cl2](bmic= bis …

Four platinum (II) complexes of N-cyclobutyl-1R, 2R-diaminocyclohexane with different
bidentate dicarboxylates (1 oxalate, 2 malonate, 3 1, 1-cyclobutanedicarboxylate and 4 3 …

The biological activity of cm and trans complexes of formula [PtCl2 [HN C (OMe) Me] 2] has
been investigated. The iminoether ligands can have either E or Z configuration about the C …

Over a decade has passed since the initial observation that neutral platinum amine
coordination compounds with cis configuration of labile groups were effective …

Shortly after the discovery of the cytostatic activity of cis-diamminedichloroplatinum
(II)(cisplatin)(1) it was suggested that the mechanism of antitumor activity of cisplatin …

Cisplatin is routinely employed for the treatment of testicular, ovarian cancer and head/neck
tumors. Typical doses administrated to patients are 100 mg/day for up to five days. It is …

Publisher Summary Cisplatin (cis-diamminedichloroplatinum II) is one of the group of
platinum coordination complexes, which possess antibiotic activity. Cisplatin causes the …

Six platinum (II) complexes of the general formula [Pt (cbdc)(HLn) 2](1–6; cbdc= cyclobutane‐
1, 1‐dicarboxylate and HL1–HL6= benzyl‐substituted 6‐benzylamino‐2‐chloro‐9 …

This paper is a focused review of our recent efforts to produce multi-nuclear platinum anti-
cancer complexes that preferentially target adenine residues in DNA. Multi-nuclear platinum …

A new tetrafunctional dinuclear platinum complex trans, trans-[{PtCl2 (NH3)} 2 (piperazine)]
with sterically rigid linking group was designed, synthesized and characterized. In this novel …